Information technology advancements have transformed all aspects of human life, especially professional occupations, leading to significant changes in finance, Auditing, and accounting. The widespread adoption of information systems and enterprise resource planning (ERP) systems in organizations has made the use of technology in Auditing a necessity. This study presents an optimal and practical model for the application of information technology in Auditing, considering substantive tests, control tests, and audit risks. The research method is field-based and employs factor analysis. The statistical population includes individuals active in the Auditing profession, and questionnaire data were collected in the year (2023/2024). To implement the mixed method of this study, research variables were first identified using a multidimensional grounded theory approach through interviews and literature review. The final influential factors were determined using the Loevshé index. The research questions were analyzed by factor analysis, and the optimal model was proposed. The findings indicate that audit risk, substantive audit tests, control tests, audit sampling, and audit time budget significantly influence the optimal and practical model of information technology application in Auditing with respect to substantive tests, control tests, and audit risks. Overall, the use of information technology reduces time and costs while increasing accuracy and efficiency. However, the involvement of information technology introduces several risks, such as unauthorized access to and modification of data.